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BC bio-crispr-screens-library-design

CRISPR library design for genetic screens. Covers sgRNA selection, library composition, control design, and oligo ordering. Use when designing custom sgRNA libraries for knockout, activation, or interference screens.

FreedomIntelligence/OpenClaw-Medical-Skills Agent Skills author: FreedomIntelligence 3 files · 1 script body ≈ 3 480 tokens Open the sourcegithub.com↗ analyzed 13 h ago

CRISPR library design for genetic screens.

As a process C 56/100 · Has gaps — weak spots: result and completion, when it triggers, inputs and preconditions

GeneratorSoftware developmentData and analyticsWriting and documentstype and topics are labelled automatically from the skill text
Runs in: Claude / Claude Code ChatGPT / Codex Gemini CLI Cursor GitHub Copilot / VS Code Qwen Code Kimi Code CLI Z.ai (GLM) DeepSeek (Deep Code) Mistral Vibe LangChain (deepagents) OpenClaw Goose OpenCode
JSON
Technical rating
B
93/100
safety, quality, tests
Safety 60%
100
Quality 40%
82
Run on models
none yet
Process rating
C
56/100
Has gaps
Result and completion w 14
0
Inputs and preconditions w 11
0
Progress reporting w 2
0
the three weakest of ten parameters · all ten

How to improve

    For the model run — optional
    • Your own cases (evals/evals.json, 4–6 real requests with expected answers): the full check would then run those instead of a model-drafted suite.
    • A spec.yaml with trigger phrases and assertions — a behaviour contract for CI; `skilltest init` writes a template.

    Guard findings · 0

    ✓ No critical or high findings

    Files scanned: 3. Evidence is masked. Grey chips explain why severity was lowered.

    Against the Agent Skills spec

    • note frontmatter-key unknown frontmatter key "tool_type"
    • note frontmatter-key unknown frontmatter key "primary_tool"

    Process rating: all ten parameters 56/100

    • 0Result and completion. Does not say what the result is
    • 0Inputs and preconditions. Does not say what the process needs to start
    • 0Progress reporting. Says nothing while it works
    • 20When it triggers. No condition that starts the skill
    • 30Running it twice. 3 mutating operations with no state check
    • 50Failures and branches. 0 branches, has a failure section
    • 100Tools and files. No external tools needed
    • 100Steps. 6 steps
    • 100Consistency. Name and required fields are in place
    • 100Execution cost. Instruction body is 3480 tokens
    • low 10 top-level sections: this looks like several domains in one skill

    Everything here is measured from the skill text rather than judged by a model, so the numbers are checkable. A parameter weighs more when it is a more common reason for the process to stall.

    Quality signals

    • +5Description has no quoted example phrases that should trigger the skill
    • +4Description does not say when NOT to use the skill (false activations)
    • +3Output format is not stated: the model decides each time
    • +1No license
    • +2Single-language instructions
    • +3Description length 216: enough signal without eating the budget
    • +4Structure: 11 headings
    • +3Step-by-step instructions: 6 items
    • +4Has examples (8 code blocks)

    Quality base 70; lint remarks subtract, signals add up to 100. Result: 82.